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Cardiomyopathies - From Basic Research to Clinical Management
Cardiomyopathy means "heart (cardio) muscle (myo) disease (pathy)". Currently, cardiomyopathies are defined as myocardial disorders in which the heart muscle is structurally and/or functionally abnormal in the absence of a coronary artery disease, hypertension, valvular heart disease or congenital heart disease sufficient to cause the observed myocardial abnormalities. This book provides a comprehensive, state-of-the-art review of the current knowledge of cardiomyopathies. Instead of following the classic interdisciplinary division, the entire cardiovascular system is presented as a functional unity, and the contributors explore pathophysiological mechanisms from different perspectives, including genetics, molecular biology, electrophysiology, invasive and non-invasive cardiology, imaging methods and surgery. In order to provide a balanced medical view, this book was edited by a clinical cardiologist.
Part 1 Classification, Evaluation and
Management of Cardiomyopathies 1
Chapter 1 Classification and Definitions of Cardiomyopathies 3
Chapter 2 Management of Hypertrophic
Obstructive Cardiomyopathy
with a Focus on Alcohol Septal Ablation 21
Chapter 3 Hypertrophic Cardiomyopathy
in Infants and Children 33
Luis E. Alday and Eduardo Moreyra
Chapter 4 Quality of Life in Dilated Cardiomyopathy
with Refractory Chronic Heart Failure
Undergoing Devices Implantation 69
Chapter 5 Peripartum Cardiomyopathy:
A Systematic Review 83
Chapter 6 Cardiomyopathy Detection from
Electrocardiogram Features 117
Chapter 7 Prevention of Sudden Cardiac
Death in Patients with Cardiomyopathy 135
Chapter 8 Biomarker for
Cardiomyopathy-B-Type Natriuretic Peptide 167
Part 2 Pathophysiology and Genetics of Cardiomyopathies 183
Chapter 9 Heart Muscle and Apoptosis 185
Chapter 10 Cardiac Myocytes and Mechanosensation 201
Chapter 11 Dobutamine-Induced Mechanical Alternans 213
Chapter 12 MicroRNAs Telltale Effects on
Signaling Networks in Cardiomyopathy 223
Chapter 13 Intercellular Connections in
the Heart: The Intercalated Disc 245
Chapter 14 Familial Hypertrophic Cardiomyopathy-Related
Troponin Mutations and Sudden Cardiac Death 277
Chapter 15 Consequences of Mutations in Genes Encoding
Cardiac Troponin C, T and I – Molecular Insights 303
Chapter 16 Cardiomyopathies Associated with
Myofibrillar Myopathies 353
Chapter 17 Functional Consequences of
Mutations in the Myosin Regulatory Light
Chain Associated with Hypertrophic Cardiomyopathy 383
Chapter 18 Role of Genetic Factors
in Dilated Cardiomyopathy 409
Part 3 Cardiomyopathies and Imaging Methods 423
Chapter 19 Role of Advanced Cardiac Magnetic Resonance
Imaging in Atypical Cardiomyopathies such as
Stress-Induced Cardiomyopathie and Left-Ventricular
Non-Compaction Cardiomyopathy 425
Chapter 20 The Use of Contrast-Enhancement Cardiovascular
Magnetic Resonance Imaging in Cardiomyopathies 439
Part 4 Metabolic and Drug-Induced Cardiomyopathies 461
Chapter 21 The Evolving Face of Heart Failure
Associated with Elevated Cardio-Metabolic Risk Factors 463
Chapter 22 Diabetic Cardiomyopathy: Cardiac Changes,
Pathophysiological Mechanisms, Biologic Markers,
and the Available Therapeutic Armamentarium 487
Chapter 23 Insulin Resistance and Cardiomyopathy 513
Chapter 24 Taurine Depletion-Related
Cardiomyopathy in Animals 537
Chapter 25 Thyrotoxic Cardiomyopathy 553
Chapter 26 Drug-Induced Cardiomyopathies 581
Chapter 27 Anthracycline Cardiotoxicity 621
Chapter 28 Cardiotonic Steroids and Cardiac Fibrosis 645
Part 5 Takotsubo Cardiomyopathy 663
Chapter 29 Stress-Induced Cardiomyopathy: Clinical Observations 665
Chapter 30 Takotsubo Cardiomyopathy 683
Chapter 31 Pathology of Takotsubo (Ampulla) Cardiomyopathy 709
Chapter 32 Torsades de Pointes in
Takotsubo Cardiomyopathy with QT Prolongation 727
Chapter 33 Torsades de Pointes Associated with
Takotsubo Cardiomyopathy: Is It Preventable? 737
Part 6 Chagas Heart Disease 747
Chapter 34 Chagas Heart Disease 749
Chapter 35 Chagasic Cardiomyopath
[else]
Cardiomyopathy means "heart (cardio) muscle (myo) disease (pathy)". Currently, cardiomyopathies are defined as myocardial disorders in which the heart muscle is structurally and/or functionally abnormal in the absence of a coronary artery disease, hypertension, valvular heart disease or congenital heart disease sufficient to cause the observed myocardial abnormalities. This book provides a comprehensive, state-of-the-art review of the current knowledge of cardiomyopathies. Instead of following the classic interdisciplinary division, the entire cardiovascular system is presented as a functional unity, and the contributors explore pathophysiological mechanisms from different perspectives, including genetics, molecular biology, electrophysiology, invasive and non-invasive cardiology, imaging methods and surgery. In order to provide a balanced medical view, this book was edited by a clinical cardiologist.
Part 1 Classification, Evaluation and
Management of Cardiomyopathies 1
Chapter 1 Classification and Definitions of Cardiomyopathies 3
Chapter 2 Management of Hypertrophic
Obstructive Cardiomyopathy
with a Focus on Alcohol Septal Ablation 21
Chapter 3 Hypertrophic Cardiomyopathy
in Infants and Children 33
Luis E. Alday and Eduardo Moreyra
Chapter 4 Quality of Life in Dilated Cardiomyopathy
with Refractory Chronic Heart Failure
Undergoing Devices Implantation 69
Chapter 5 Peripartum Cardiomyopathy:
A Systematic Review 83
Chapter 6 Cardiomyopathy Detection from
Electrocardiogram Features 117
Chapter 7 Prevention of Sudden Cardiac
Death in Patients with Cardiomyopathy 135
Chapter 8 Biomarker for
Cardiomyopathy-B-Type Natriuretic Peptide 167
Part 2 Pathophysiology and Genetics of Cardiomyopathies 183
Chapter 9 Heart Muscle and Apoptosis 185
Chapter 10 Cardiac Myocytes and Mechanosensation 201
Chapter 11 Dobutamine-Induced Mechanical Alternans 213
Chapter 12 MicroRNAs Telltale Effects on
Signaling Networks in Cardiomyopathy 223
Chapter 13 Intercellular Connections in
the Heart: The Intercalated Disc 245
Chapter 14 Familial Hypertrophic Cardiomyopathy-Related
Troponin Mutations and Sudden Cardiac Death 277
Chapter 15 Consequences of Mutations in Genes Encoding
Cardiac Troponin C, T and I – Molecular Insights 303
Chapter 16 Cardiomyopathies Associated with
Myofibrillar Myopathies 353
Chapter 17 Functional Consequences of
Mutations in the Myosin Regulatory Light
Chain Associated with Hypertrophic Cardiomyopathy 383
Chapter 18 Role of Genetic Factors
in Dilated Cardiomyopathy 409
Part 3 Cardiomyopathies and Imaging Methods 423
Chapter 19 Role of Advanced Cardiac Magnetic Resonance
Imaging in Atypical Cardiomyopathies such as
Stress-Induced Cardiomyopathie and Left-Ventricular
Non-Compaction Cardiomyopathy 425
Chapter 20 The Use of Contrast-Enhancement Cardiovascular
Magnetic Resonance Imaging in Cardiomyopathies 439
Part 4 Metabolic and Drug-Induced Cardiomyopathies 461
Chapter 21 The Evolving Face of Heart Failure
Associated with Elevated Cardio-Metabolic Risk Factors 463
Chapter 22 Diabetic Cardiomyopathy: Cardiac Changes,
Pathophysiological Mechanisms, Biologic Markers,
and the Available Therapeutic Armamentarium 487
Chapter 23 Insulin Resistance and Cardiomyopathy 513
Chapter 24 Taurine Depletion-Related
Cardiomyopathy in Animals 537
Chapter 25 Thyrotoxic Cardiomyopathy 553
Chapter 26 Drug-Induced Cardiomyopathies 581
Chapter 27 Anthracycline Cardiotoxicity 621
Chapter 28 Cardiotonic Steroids and Cardiac Fibrosis 645
Part 5 Takotsubo Cardiomyopathy 663
Chapter 29 Stress-Induced Cardiomyopathy: Clinical Observations 665
Chapter 30 Takotsubo Cardiomyopathy 683
Chapter 31 Pathology of Takotsubo (Ampulla) Cardiomyopathy 709
Chapter 32 Torsades de Pointes in
Takotsubo Cardiomyopathy with QT Prolongation 727
Chapter 33 Torsades de Pointes Associated with
Takotsubo Cardiomyopathy: Is It Preventable? 737
Part 6 Chagas Heart Disease 747
Chapter 34 Chagas Heart Disease 749
Chapter 35 Chagasic Cardiomyopath
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